Thanks for the reply CAP.
I checked the sender. log and it contains this error repeatededly
----------------------------------------------------------------------------------------------------------------------------------------------------
Error during connection to \\CentralSite\MyDomain\SMS_Site (53).
Error is considered fatal.
Cannot connect to server CentralSite.MyDomain.com at remote site CEN, won't try send requests going to site CEN for an hour or until there are no active send requests.
Could not establish connection.
Attempt to connect failed.
------------------------------------------------------------------------------------------------------------------------------------------------------